Growth Cone Stop Signals: Inviting to Stay or Sending Away?
نویسندگان
چکیده
منابع مشابه
Sending signals dynamically.
Proteins mediate transmission of signals along intercellular and intracellular pathways and between the exterior and the interior of a cell. The dynamic properties of signaling proteins are crucial to their functions. We discuss emerging paradigms for the role of protein dynamics in signaling. A central tenet is that proteins fluctuate among many states on evolutionarily selected energy landsca...
متن کاملSignals in limb development: STOP, GO, STAY and POSITION.
Cell-to-cell interactions in early limb development are considered within the framework of the extracellular signals STOP, GO, STAY and POSITION, a classification which emphasises that the signals are elective rather than instructive, and that complexity arises from cells' response. Patterning in the limb is analysed in terms of signals that specify positional values along the anteroposterior a...
متن کاملSending and Receiving Hedgehog Signals.
Communication between cells pervades the development and physiology of metazoans. In animals, this process is carried out by a relatively small number of signaling pathways, each consisting of a chain of biochemical events through which extracellular stimuli control the behavior of target cells. One such signaling system is the Hedgehog pathway, which is crucial in embryogenesis and is implicat...
متن کاملOncogenic herpesviruses sending mixed signals.
Human herpesvirus infections are generally asymptomatic in immune-competent hosts; however, immune dysfunction can unveil inherent oncogenic properties associated with Epstein-Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) infection. Although these viruses were first discovered in human tumor specimens in 1964 and 1994, respectively, it was discovered later on that large proportions o...
متن کاملhMENA11a, a hMENA isoform sending survival signals
Human MENA(11a) (hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA(11a) as a marker of HER3 act...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2006
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2997-06.2006